What Is SLU-PP-332?
SLU-PP-332 is a synthetic small-molecule compound developed as a pan-agonist of the estrogen-related receptors (ERRα, ERRβ, and ERRγ). Estrogen-related receptors are nuclear receptors that regulate transcriptional programmes central to mitochondrial biogenesis, oxidative metabolism, and cellular energy expenditure. Unlike classical estrogen receptors, ERRs do not bind estrogen and are instead regulated by co-activators and synthetic ligands such as SLU-PP-332. TrueCanPeptides supplies SLU-PP-332 5mg for laboratory research purposes.
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Mechanism of Action
SLU-PP-332 binds and activates all three ERR isoforms (ERRα, ERRβ, ERRγ), triggering transcriptional activation of ERR target genes. ERRα and ERRγ are recognised as master regulators of mitochondrial oxidative metabolism, controlling expression of genes involved in fatty acid oxidation, the tricarboxylic acid (TCA) cycle, oxidative phosphorylation, and mitochondrial biogenesis through interactions with the PGC-1α/β co-activator system.
In preclinical rodent studies, SLU-PP-332 has been examined as a potential exercise mimetic — a compound that activates molecular pathways typically induced by endurance exercise. Research has investigated whether SLU-PP-332 can upregulate PGC-1α target gene networks, increase mitochondrial density markers, and alter oxidative fibre composition in skeletal muscle tissue in animal models.
Research Applications
SLU-PP-332 has been studied across the following preclinical research domains:
- Mitochondrial biogenesis: Investigated in skeletal muscle and other tissue models for upregulation of PGC-1α-responsive gene programmes and mitochondrial density markers.
- Oxidative metabolism: Studied for effects on fatty acid oxidation gene expression and TCA cycle capacity in cellular and rodent models.
- Exercise mimetic research: Examined in rodent exercise models for whether ERR pan-agonism recapitulates molecular signatures associated with endurance training adaptations.
- ERR receptor biology: Used as a tool compound to characterise ERRα/β/γ receptor function and ligand-dependent transcriptional regulation.
- Metabolic disease models: Investigated in preclinical models of metabolic dysfunction where oxidative capacity has been characterised.
All listed applications are investigational. Explore the TrueCanPeptides Research Hub →
Storage & Handling
SLU-PP-332 should be stored as a solid powder at −20°C, protected from moisture and light. Dissolve in DMSO for most research applications, following validated solubility protocols for the specific assay system. Prepare working solutions fresh where practical; aliquot and store at −80°C for extended periods. Avoid repeated freeze-thaw cycles.
Full storage guidance is in the TrueCanPeptides Storage Guide. See quality and purity standards.
Related Research
Researchers investigating mitochondrial biology and metabolic pathways may also find these guides useful:
- SS-31 (Elamipretide) — mitochondria-targeting tetrapeptide studied in cardiolipin and oxidative stress research
- 5-Amino-1MQ — NNMT inhibitor studied in NAD+ and cellular energy pathway research
- AOD9604 — hGH fragment studied in lipolytic pathway and metabolic research
Disclaimer: This content is intended for educational and research purposes only. The compounds discussed on this page are not approved for human therapeutic use by Health Canada or any other regulatory authority. They are not intended to diagnose, treat, cure, or prevent any disease or medical condition. TrueCanPeptides supplies research compounds strictly for in vitro and laboratory research use. All information presented is derived from published preclinical and early-phase research literature and does not constitute medical advice. Consult a qualified healthcare professional before making any health-related decisions.