What Is IGF-1 LR3?
IGF-1 LR3, also known as long arginine extended insulin-like growth factor 1, is a synthetic analogue of endogenous insulin-like growth factor 1 (IGF-1). This research compound has been investigated in scientific contexts for its structural modifications and signalling properties. Understanding IGF-1 LR3 is critical for researchers working in cell biology and growth factor research.
Structural Differences From IGF-1
IGF-1 LR3 differs from natural IGF-1 through two key modifications: an arginine substitution at position 3 and a 13 amino acid extension at the C-terminus. These structural alterations were engineered specifically to alter binding properties. Research has suggested that these modifications result in reduced binding to insulin-like growth factor-binding proteins (IGFBPs), which theoretically could extend its signalling window in research models. However, all investigations remain in preclinical contexts.
Research Areas
IGF-1 LR3 has been investigated primarily through cellular signalling research via the insulin-like growth factor 1 receptor (IGF-1R). Preclinical studies have examined its interactions within in vitro and animal model systems. The compound serves as a research tool for understanding growth factor receptor activation and downstream signalling cascades. Scientists studying cell proliferation, differentiation, and metabolism have utilized IGF-1 LR3 as an experimental reagent.
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Storage Notes
IGF-1 LR3 is supplied in lyophilized form and requires storage at -20°C or lower for optimal stability. This compound is particularly sensitive to freeze-thaw cycles, which can compromise peptide integrity and biological activity. Researchers should minimize the number of freeze-thaw events and follow proper reconstitution protocols.
Purity Standards
Research-grade IGF-1 LR3 must meet rigorous quality and purity standards, typically 98-99% pure. All compounds should be accompanied by comprehensive certificate of analysis documentation confirming identity, purity, and absence of contaminants. Verification of these documents ensures reproducibility and scientific integrity in research.
Research Disclaimer
For research purposes only. Not intended for human use. This content is educational and does not constitute medical advice.