What Is Melanotan 1?

Melanotan 1 (MT-1), also known by its INN name afamelanotide, is a synthetic alpha-melanocyte-stimulating hormone (α-MSH) analogue. This research compound has been extensively studied in scientific literature examining melanocortin receptor signalling and pigmentation biology. MT-1 represents an important model compound for investigating the melanocortin system in controlled research environments.

The Melanocortin System

The melanocortin system is a complex physiological network involving multiple receptor subtypes and their endogenous ligands. MT-1 was engineered specifically to act as a selective agonist at the melanocortin 1 receptor (MC1R), which is primarily expressed in melanocytes. This receptor selectivity distinguishes MT-1 from other melanocortin analogues and makes it a valuable research tool for understanding MC1R-mediated signalling pathways.

Research Background

MT-1 has been investigated in preclinical and clinical research contexts, particularly in dermatology and pigmentation research. Studies have examined its effects on melanin synthesis and distribution within skin tissue. The compound serves as a research model for understanding how melanocortin receptor activation influences pigmentation mechanisms. However, human clinical evidence remains limited and preliminary in nature.

Researchers studying melanocortin biology can access high-purity MT-1 10mg through TrueCanPeptides’ Research Hub.

MT-1 vs MT-2: Receptor Selectivity

MT-1 and MT-2 differ significantly in their receptor activation profiles. While MT-1 demonstrates selectivity for MC1R, MT-2 exhibits broader activity across multiple melanocortin receptors (MC1R, MC3R, MC4R, and MC5R). This difference in receptor selectivity makes each compound valuable for distinct research applications investigating specific aspects of melanocortin signalling.

Storage and Purity

MT-1 is supplied in lyophilized form and must be stored at -20°C or lower. Researchers should consult the peptide storage guide and reconstitution guide for proper handling. All MT-1 from TrueCanPeptides meets stringent quality and purity standards and is accompanied by detailed certificate of analysis documentation.

Research Disclaimer

For research purposes only. Not intended for human use. This content is educational and does not constitute medical advice.